Record Details

Callard, Ian P;Klotz, Kathleen L
Sensitivity of parameters of estrogen action in the iguanid lizard Dipsosaurus dorsalis
General and Comparative Endocrinology
Journal Article
Dipsosaurus dorsalis
The effects of different dose levels of estradiol 17 beta was studied using several parameters of estrogenic activity (liver weight, liver glycogen, plasma protein concentration, and oviduct weight) in the oviparous lizard, Dipsosaurus dorsalis. All parameters responded to a dose of 0.1 ug estradiol 17 beta/day for 14 days. Analysis of the data revealed no significant deviations from linearity of the response to the hormone for liver weight, but significant deviations were observed in the other three parameters. The results are discussed in reference to other published work in an attempt to arrive at a physiologic dose of estradiol for vertebrates in general.